| 摘要 |
PURPOSE:To provide an agent for improving the antitumor activity of 5-fluorouracils, by using a pentose phosphoric acid ester and/or purine nucleotides as active components. CONSTITUTION:The agent contains the compounds selected from pentose phosphoric acid esters such as ribose-1-phosphate, and purine nucleotides such as adenosine-5'-triphosphate, guanosine-5'-triphosphate, etc. The amount of the above compound is >=0.5mol, preferably 0.5-5mol per 1mol of 5-fluorouracil. Preferably, both compounds are compounded together before hand, and administered at the same time. The addition of the compound is effective to suppress the proliferation of cultured cancer cells, elongate the life of animal affected with ascites carcinoma, and suppress the proliferation of scirrhous cancer. |
