| 摘要 |
NEW MATERIAL:An antitumor component: SPF 10-11 [elementary analyses: C 37.2-39.4%, H 5.6-6.5%, N 0.1-2.3%, O 56.9-46.3%, Ash 0.2-2.5%; decomposition point: browning at 165 deg.C and darkening at 240 deg.C with decomposition; specific rotatory power [alpha]<20>D=+95 deg.-+130 deg. (C=1.00); pH is 6.2-6.8 in 0.1% aqueous solution; color: white (freeze-dried); color reactions: positive to the Rowry reaction, negative to orcinol-hydrochloric acid reaction; molecular weight is more than 20X10<4> (according to the ultracentrifugation method); solubility: soluble in water, sparingly soluble or insoluble in methanol, etc.] USE:Antitumor agent. PREPARATION:A microorganism in Streptococcus, capable of producing an antitumor, SPF 10-11, is cultured and penicillin or its relating substance is added to the culture mixture in an appropriate period and cultivation is continued. The cell bodies are centrifuged off, the filtrate is concentrated and purified to give the objective antitumor agent, SPF 10-11. |
