| 摘要 |
2-Substituted triazolo[4, 3 -a]pyridin-3(2H)-ones represented by the formula
<CHEM>
wherein
R<1> is hydrogen or lower alkyl located in the 5, 6, 7 or 8 position of the 1,2,4-triazolo(4,3-a]pyridin-3(2H) -one ring and having 1 to 4 carbon atoms, and
CF3 is located in the 2,3 or4 position of the phenyl ring and the pharmaceutically acceptable acid addition salts thereof, which exhibit excellent anti-depressive activity and are useful as anti-depression agents. The invention also provides a process for the preparation of said compounds, a pharmaceutical composition comprising at least one of said compounds and use of said compounds in the treatment of depression |
