发明名称 Process for the preparation of nitroguanidine derivatives.
摘要 A process for the production of a compound of formula (I)whereinR1 is hydrogen or C1-C4-alkyl;R2 is hydrogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkinyl, C3-C6-cycloalkyl or a radical -CH2B;A is selected from the group consisiting of 2-chloropyrid-5-yl, tetrahydrofuran-3 -yl, 5-methyl-tetrahydrofuran-3-yl or 2-chlorothiazol-5-yl; andB is phenyl, 3-pyridyl or thiazolyl, which are optionally substituted by one to three substituents selected from the group consisting of C1-C3-alkyl, C1-C3-halogenalkyl, cyclopropyl, halogencyclopropyl, C2-C3-alkenyl, C2-C3-alkinyl, C1-C3-alkoxy, C2-C3-halogenalkenyl, C2-C3-halogenalkinyl, C1-C3-halogenalkoxy, C1-C3-alkylthio, C1-C3-halogenalkylthio, allyloxy, propargyloxy, allylthio, propargylthio, halogenallyloxy, halogenallylthio, halogen, cyano or nitro;and optionally the possible E/Z isomers, E/Z isomeric mixtures and/or tautomers thereof, respectively in free form or in salt form;characterised in that a compound of formula (II)whereinR1, R2 and A have the same significances as in formula (I), andX is O or S;is hydrolysed with a strong acid at a pH below 2; at a temperature between 50 and 100° C; and in a solvent selected from the group consisting of water, alcohols, ethers or mixtures thereof. The compounds of formula (I) are suitable for the preparation of pesticides.
申请公布号 ZA200004179(B) 申请公布日期 2001.04.25
申请号 ZA20000004179 申请日期 2000.08.16
申请人 NOVARTIS AG. 发明人 PETER MAIENFISCH;THOMAS RAPOLD;HENRY SZCZEPANSKI
分类号 C07D277/20;C07D213/61;C07D213/89;C07D273/04;C07D277/32;C07D285/34;C07D307/14;C07D413/06 主分类号 C07D277/20
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