PROCESO PARA PREPARAR ACIDO DE 1,2,4-OXADIAZOL BENZOICO O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE ESTE QUE COMPRENDE HACER REACCIONAR UN METIL ESTER DE ACIDO CIANOBENZOICO CON HIDROXILAMINA, ACILAR CON CLORURO DE HALOBENZOILO, CONDENSAR E HIDROLIZAR E

摘要

Provided herein are processes for the preparation of compounds useful for the treatment, prevention or management of diseases associated with a nonsense mutation. More specifically, provided herein are processes for the synthesis of 1,2,4-oxadiazoles. In particular, provided herein are processes useful for the preparation of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid.