| 摘要 |
<p>Compounds having the formula: <CHEM> wherein R<1> represents the characterizing group of an alpha -amino acid of the type normally found in proteins; R<2> and R<3> are, independently, hydrogen or C1-C3-alkyl; Z is hydrogen, C1-C6-alkyl, C1-C6-alkanoyl phenyl-C1-C3-alkyl, phenyl-(X)n-C1-C3-alkanoyl, or an amino-protecting group, Z is hydrogen or C1-C6-alkyl, X is oxygen or sulfur, m is 0 or 1 and n is 0, 1, 2 or 3; provided that when R<2> and R<3> are both alkyl, they must be identical; and the salts thereof, are disclosed herein and are useful as immunoregulating agents. The compounds of formula 2 are prepared from antibiotic A53868 factor A by conventional peptide synthesis. Also disclosed as immunoregulating agents are fosfomycin and its derivatives.</p> |
