METHOD FOR PRODUCING DERIVATIVES OF PROSTAGLANDINE

摘要

NEW MATERIAL:A combination of prostaglandin and D ring of steriod hormone bonded directly or via a binding agent. EXAMPLE:A combination of esteradiol and PGF2alpha of the formula [R is (CH2)n; n is 1 or 2; m is 0 or 1]. USE:Delivery promotors, uterus implantation inhibitors, physiological regulators having actions, e.g. delivery promotion and abnormal menstruation regulation. PROCESS:The carboxyl group of a prostaglandin is reacted with the hydroxyl group bonded to the D ring of steroid hormone molecule to form an ester of formula wherein m is o, Alternatively, a steroid hormone molecule is combined with a prostaglandin via a binding agent having the formula X (CH2)n COOH (X is halogen), HOOC (CH2)n COOH, etc. to give the objective substance of the formula wherein m is l.