发明名称 |
Enzyme derivatives, process for preparing them and pharmaceutical compositions containing them. |
摘要 |
<p>A derivative of streptokinase-human plasminogen activator complex, in which the active catalytic site essential for fibrinolytic activity is blocked by a 2- or 4-aminobenzoyl group, is useful in treating venous thrombosis. The blocking group is removable by hydrolysis such that the first order rate is in the range 0.7x10-5sec-1 to 2.5x10-5sec-1 in isotonic aqueous media at pH 7.4 at 37 DEG C.</p> |
申请公布号 |
EP0091240(A2) |
申请公布日期 |
1983.10.12 |
申请号 |
EP19830301651 |
申请日期 |
1983.03.24 |
申请人 |
BEECHAM GROUP PLC |
发明人 |
SMITH, RICHARD ANTHONY GODWIN |
分类号 |
C12N9/68;A61K38/00;A61K38/46;A61P7/02;C07K14/315;C12N9/70;C12N9/72;C12N9/96;(IPC1-7):12N9/96;12N9/70;61K37/54 |
主分类号 |
C12N9/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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