| 摘要 |
PURPOSE:To make it possible to prepare a microcapsule not damaging the physiological activity of the core substance thereof, in preparing the microcapsule, by forming the shell skin thereof from a polyionic complex layer. CONSTITUTION:An org. solvent solution of a weak acidic high-molecular electrolyte is used as an oil phase O and an aqueous solution of enzyme or vitamin is dispersed in said oil phase to form a primary W1/O type emulsion containing said aqueous solution as a first aqueous phase W1. This emulsion is added to a second aqueous phase W2 comprising an aqueous medium to form a secondary (W1/O)/W2 type emulsion and the org. solvent contained in the oil phase is removed from said emulsion through W2 by evaporation. In the next step, alkali such as NaOH is added to raise the pH of the second aqueous medium phase W3 of the secondary emulsion to change the weak acidic high-molecular electrolyte to a charged type one. This electrolyte comes to a shell skin comprising an insoluble hydrogel film due to a polyionic complex between said electrolyte and a strong basic high-molecular electrolyte and a microcapsule not damaging the core material thereof is formed. |
