摘要 |
A compound of formula (1):- <CHEM> and pharmaceutically acceptable salts thereof, where R<1> and R<2> are the same or different and are C1-6 alkyl or with the nitrogen atom to which they are attached form a pyrrolidino or piperidino group; R<3> is C1-4 alkylene; R<4> is hydrogen, C1-6 alkyl, hydroxy-C2-4alkyl; optionally substituted phenyl or phenyl (C1-6 alkyl) (the substituents being one or more C1-6 alkyl, or C1-6 alkoxy groups or halogen atoms); R<5> and R<6> are the same or different and are hydrogen, C1-6 alkyl, hydroxy C1-6 alkyl, C1-6 alkoxy-C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, optionally substituted phenyl or phenyl (C1-6 alkyl), (the substituents being one or more C1-6 alkyl or C1-6 alkoxy groups or halogen atoms or a methylenedioxo group), or optionally substituted furanyl- or thienyl- or pyridyl(C1-6 alkyl) the substituents being one or more C1-6 alkyl or C1-6 alkoxy groups); or taken together represent a C4-6 alkylene group, or taken together represent a group of formula (2):- =CR<7>R<8> (2) where R<7> is phenyl or pyridyl and R<8> is hydrogen of C1-6 alkyl, where R<1> to R<4> are as defined with reference to formula (1) with an amine of formula (19):- R<5>R<6>NH (19) and optionally converting a compound of formula (1) produced by any one of steps (a) to (f) into a salt. |