发明名称 |
Process for preparing optically active (S)-2-acetyl-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran and salts thereof. |
摘要 |
<p>(S)-(+)-2-acetyl-7-(2,3-epoxypropoxy)benzofuran (SEBF) is prepared by subjecting 2-acetyl-7-hydroxybenzofuran and [R]-glycidol to dehydration condensation in an inert organic solvent in the presence of triphenylphosphine and a dialkyl azodicarboxylate. The [S]-(+)-2-actyl-7-(2,3-epoxypropoxy) benzofuran can be easily converted into [S]-2-acetyl-7-(2-hydroxy-3-isopropylaminopropoxy) benzofuran ([S]-befunolol) or salts thereof which are useful as a beta -adrenergic blocking agent, by reacting it with isopropylamine. </p> |
申请公布号 |
EP0089037(A2) |
申请公布日期 |
1983.09.21 |
申请号 |
EP19830102460 |
申请日期 |
1983.03.12 |
申请人 |
KAKEN PHARMACEUTICAL CO., LTD. |
发明人 |
NAKANO, JUN;NAKANISHI, TERUO;KIMURA, KAZUHIKO |
分类号 |
C07D301/02;C07D307/86;C07D407/12;(IPC1-7):07D407/12;07D307/86 |
主分类号 |
C07D301/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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