发明名称 |
ANTITUMOR GLYCOSIDES, THEIR PREPARATION, USE AND COMPOSITIONS THEREOF |
摘要 |
<p>Anthracycline glycosides of the formula I I wherein R is hydrogen or hydroxy, one of R1 and R2 is methyl and the other of R1 and R2 is hydroxy, and pharmaceutically acceptable acid addition salts thereof, which are useful in treating certain mammalian turmors, are prepared by condensing daunomycinone with certain novel sugars in an inert organic solvent and in the presence of a soluble silver salt and a dehydrating agent to form the corresponding protected glycosides from which the protecting groups are removed. This gives the compounds wherein R is hydrogen. The former are converted to the corresponding hydroxyl compounds by treatment with bromine and sodium formate.</p> |
申请公布号 |
CA1154013(A) |
申请公布日期 |
1983.09.20 |
申请号 |
CA19800359119 |
申请日期 |
1980.08.27 |
申请人 |
FARMITALIA CARLO ERBA S.P.A. |
发明人 |
BARGIOTTI, ALBERTO;CASSINELLI, GIUSEPPE;PENCO, SERGIO;ARCAMONE, FEDERICO;DI MARCO, AURELIO |
分类号 |
C07H5/06;A61K31/70;A61K31/7008;A61K31/7024;A61K31/7028;A61K31/7034;A61K31/704;A61P35/00;A61P35/02;C07H13/08;C07H15/252;(IPC1-7):C07H15/24 |
主分类号 |
C07H5/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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