| 摘要 |
A stable, quick-acting insulin preparation is produced by dissolving a zinc-free insulin in an aqueous medium containing monovalent ions, such as sodium ions, but substantially no di- or polyvalent ions, adjusting the pH to the range of 6.9 to 8.0, preferably 7.2 to 7.8, and adding a zinc compound corresponding to 0.5 to 1.0% zinc, preferably 0.7 to 0.9% zinc, based on the weight of insulin. The preparation has a great stability against aggregation at 25 to 37<o>C and therefore lends itself to be used particularly for portable or implantable insulin delivery devices. |
