发明名称 |
NOVEL ALKYLATED PREGNANES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME |
摘要 |
The present invention relates to novel 21-alkylated steroids of the pregnane series having the formula: <IMAGE> wherein R1=alkyl (1-4 C); R2=carboxyacyl (1-18 C); X=H, F or Cl; Y=O, H(OH), H(lower acyloxy), H(F) or H(Cl) with the proviso that Y is not H(F) when X is F; and the dotted line indicates the optional presence of a double bond, to processes for their preparation and to pharmaceutical compositions containing same. The novel compounds possess strong anti-inflammatory properties, when applied locally and cause little or systemic, thymolytic, adrenolytic and salt-retaining effects. |
申请公布号 |
DE3064460(D1) |
申请公布日期 |
1983.09.08 |
申请号 |
DE19803064460 |
申请日期 |
1980.01.08 |
申请人 |
AKZO N.V. |
发明人 |
CAIRNS, JAMES;LOGAN, ROBERT THOMAS;MCGARRY, GEORGE;ROY, ROBERT GIBSON;WOODS, GILBERT FREDERICK |
分类号 |
A61K31/57;A61K31/575;A61P29/00;C07J9/00;C07J31/00;C07J41/00;(IPC1-7):07J9/00;61K31/575 |
主分类号 |
A61K31/57 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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