发明名称 |
Improved process for the production of 2-(4-(2-thiazolyloxy)phenyl)propionic acid. |
摘要 |
Improved process for the production of 2-[4-(2-thiazolyloxy)phenyl]propionic acid which comprises methylating the isopropyl, sec-butyl, tert-butyl or benzhydryl ester of 2-[4-(2-thiazolyloxy)phenyl]acetic acid with methyl bormide in dimethylformamide at -5 to 5 DEG C in the presence of powdered potassium hydroxide and hydrolyzing the ester group with sodium hydroxide at 0 - 70 DEG C in an aqueous alcohol solution. |
申请公布号 |
EP0088008(A1) |
申请公布日期 |
1983.09.07 |
申请号 |
EP19830400349 |
申请日期 |
1983.02.18 |
申请人 |
SHIONOGI & CO., LTD. |
发明人 |
HAMADA, YOSHINORI;ANDO, SATORU |
分类号 |
C07D277/20;C07D277/34 |
主分类号 |
C07D277/20 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|