| 摘要 |
Anti-protozoal 1,2,4-oxadiazole derivatives of the formula: <IMAGE> wherein R1 is amino or substituted amino; each R2 is the same or different in one or more of the 3, 4, 5 or 6 positions and is hydrogen, lower alkyl, halogen, hydroxy, alkoxy, alkylthio, arylthio, amino, substituted amino, cyano or nitro; X and Y together represent a bond or X and Y are both hydrogen; R3 is hydrogen, lower alkyl, aryl, substituted aryl or ArS.CH2-; and Ar is unsubstituted or mono-, di- or tri-substituted phenyl wherein the substituents may be the same of different, and acid addition salts thereof, methods for their preparation, formulations thereof and their use in the treatment of protozoal infections, especially malaria are described. |
