发明名称 |
CHROMANOL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION COMPRISING THEM |
摘要 |
Compounds of the formula (I): <IMAGE> (I) and salts and pro-drugs thereof, wherein: R1 is a hydrogen atom or a lower alkyl group; R2 is a hydrogen atom or a lower alkyl group; R3 is a hydrogen atom or a lower alkyl group; R4 is a hydrogen atom or an alkyl group; R5 is a lower alkyl or a substituted alkyl group; or R4 and R5 are joined so that together with the nitrogen atom to which they are attached they form a 5-, 6- or 7-membered ring optionally containing an oxygen or sulphur atom; R6 is an electron donating group; R7 is an electron withdrawing group; and the NR4R5 and OR3 moieties are trans having antihypertensive activity, pharmaceutical compositions containing them and processes for their preparation. |
申请公布号 |
DE3064286(D1) |
申请公布日期 |
1983.08.25 |
申请号 |
DE19803064286 |
申请日期 |
1980.09.08 |
申请人 |
BEECHAM GROUP PLC |
发明人 |
EVANS, JOHN MORRIS;SHOWELL, GRAHAM ANDREW;FAKE, CHARLES SYLVESTER |
分类号 |
C07D311/22;C07D311/68;C07D493/04;(IPC1-7):C07D311/68;C07D311/70;C07D311/72;A61K31/40;A61K31/44 |
主分类号 |
C07D311/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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