PROCESS FOR THE PREPARATION OF 11-BETA-HYDROXY STEROIDS

摘要

1. Process for the manufacture of 11 beta -hydroxysteroids of the general formula I see diagramm : EP0042451,P8,F1 in which the bonds ..... represent single bonds or double bonds, X represents a hydrogen atom, a fluorine atom, a chlorine atom or a methyl group, and V represents a methylene group, an ethylene group, an ethylidene group or a vinylidene group, characterized in that a 11-desoxysteroid of the general formula II see diagramm : EP0042451,P8,F2 in which ....., X and V have the meanings given above, R1 represents a hydrogen atom or an alkyl group containing from 1 to 6 carbon atoms, and R2 represents an alkyl group containing from 1 to 6 carbon atoms, is fermented with a fungal culture of the genus Curvularia.