AI-77 Compounds and pharmaceutically acceptable salts thereof

摘要

AI-77 compounds, pharmaceutically acceptable salts thereof, and a process for the preparation thereof are described, said compounds having the formulae <IMAGE> (I) <IMAGE> (II) wherein: X is NR6 or O; Y is NHR5 or combine with Z to provide a link for bonding C and C; Z is H or combines with Y to provide a link for bonding C and C; R1, R3 and R5 are each H, R', -CH2R, or -COR; R6 is H or R; R7 is H, R or CH2R; R is a hydrocarbon group consisting of a saturated or unsaturated straight or branched aliphatic group of C1 to C17, an aromatic group of C6 to C10, a cage type group of C7 to C10, a monocyclic aliphatic group of C3 to C8, an aromatic-aliphatic group of C7 to C15, a heterocyclic hydrocarbon of C1 to C9, wherein the above hydrocarbons can be substituted with one or more groups selected from halogen, oxo, carboxyl, hydroxyl, a saturated or unsaturated straight or branched aliphatic group of C1 to C5, an aromatic group of C6 to C10, a monocyclic aliphatic group of C3 to C8, an aromatic-aliphatic group of C7 to C11, alkoxy of C1 to C5, thioalkoxyl of C1 to C5, carboalkoxyl of C1 to C6, acyl of C1 to C5, acyloxy of C2 to C6 and a heterocyclic group of C1 to C9; R' is the same as R exclusive of those groups wherein unsaturated carbon or tertiary carbon is directly bonded to O or N; R2 is H, or combines with T1 to provide a link for bonding C and O in a lactone ring; T1 is OH or combines with R2 to provide a link for bonding C and O in a lactone ring; R4 is H or combines with T2 to provide a link for bonding C and O in a lactone ring; and T2 is OH or combines with R4 to provide a link for bonding C and O in a lactone ring; and pharmaceutically acceptable salts thereof.