Beta-lactam compound and a pharmaceutical composition containing the same.

摘要

beta -lactam compounds represented by the general formula: {wherein Acyl represents: [where R1 represents a hydrogen atom, a lower alkyl group having 1 to 6 carbon atoms, a substituted lower alkyl group having 1 to 6 carbon atoms (where the substituent is a cyano group, a halogen atom, a carboxyl group, a lower alkoxy-carbonyl group having 2 to 6 carbon atoms, or a carbamoyl group), or a group represented by (where R2 and R3 are same or different, and represent hydrogen atoms, lower alkyl groups having 1 to 5 carbon atoms, or a 3 to 6-membered cycloalkylidene group with the carbon atoms bonded thereto; A represents a phenyl or naphtyl group respectively substituted by (OR4)n and further optionally substituted by other group(s), R4 represents a hydrogen atom, or a lower alkanoyl group having 1 to 5 carbon atoms; @ and m represent 0 or 1; n represents an integer of 1 to 4)], or [where R5 represents a hydrogen atom, a lower alkanoyl group having 1 to 5 carbon atoms, a carbamoyl group, a lower alkyl group having 1 to 5 carbon atoms, a carbamoyl group substituted by a lower alkanoyl group having 1 to 5 carbon atoms, or a group represented by: [where R2, R3, A, R4, and @ and n have the same meanings as defined above)]; X represents a methoxy group, an azide group, an amino group, NHCOR6 (where R6 represents a lower alkyl group having 1 to 5 carbon atoms, an amino group, or a lower alkylamino group having 1 to 5 carbon atoms, S - R7 (where R7 represents a substituted or unsubstituted 5 or 6-membered monocyclic or bicyclic heterocyclic group having 1 to 5 nitrogen, oxygen or sulfur atoms), a pyridinium group, or a substituted pyridinium group; and R represents a hydrogen atom, an alkali metal, an alkaline earth metal, an organic ammonium group or an ester residue readily hydrolyzable in vivo. In spite of the above definition, where X is a methoxy group. R1 is a hygrogen atom, a lower alkyl group having 1 to 6 carbon atoms, or a substituted lower alkyl group having 1 to 6 carbon atoms (where the substituent is a cyano group, a halogen atom, or a carbamoyl group) } have a strong anti-microbial activities against a wide range of Gram positive and Gram negative bacteria.