发明名称 1-(Substituted-aminoalkoxyphenyl)-2-methylene-1-alkanones, compositions and use
摘要 1-(Substituted-aminoalkoxyphenyl)-2-methylene-1-alkanones, a class of compounds possessing anti-allergic properties for use in the treatment of allergic conditions, such as asthma prepared by etherifying an alkanoylphenol with an aminoalkyl halide, converting the ether formed to a salt of Mannich base by reacting it with a salt of a secondary amine in the presence of formaldehyde or paraformaldehyde and treating the Mannich salt with a weak base to deaminate the same and form the final product.
申请公布号 US4390537(A) 申请公布日期 1983.06.28
申请号 US19820379604 申请日期 1982.05.19
申请人 MERCK & CO., INC. 发明人 CRAGOE, JR., EDWARD J.
分类号 C07D295/092;(IPC1-7):C07D295/10;A61K31/53 主分类号 C07D295/092
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