| 摘要 |
PURPOSE:The thioalkylation of a halogenated alkyl is followed by amination of the product and conversion of the resultant NH2 group into NCS to give the titled compound used as a flavor through a simplified process. CONSTITUTION:A dihalogenated alkyl or formulaI(X is halogen; n is 5-8) is made to react with a thioalkylation reagent such as CH3SNa or Na2S and one of X in formulaIis thioalkylated. Then, the other X is aminated with an aminating reagent such as NaHN2 or NH3 aqueous solution to prepare alkylthioalkylamine of formula II (R is methyl, ethyl). Finally, the amino group of the product is converted into NCS with a compound of formula III. The process of the prevent invention consists only of three stages, thus being very useful in practice. The compound of formula IV is useful as a flavor smelling WASABI- like odor. |
