10-BROMOSANDWICINE AND 10-BROMOISOSANDWICINE, AS WELL AS THEIR ADDITIONS SALTS WITH PHARMACOLICAL ACCEPTABLE ACIDS PROCESS FOR THEIR PREPARATION AND THEIR USE

摘要

10-bromosandwicine and 10-bromoisosandwicine and acid addition salts thereof are disclosed. There novel compounds possess valuable pharmacological properties e.g. heart rhythm regulatory properties. Furthermore they are valuable intermediates for the preparation of 10-brominated Nb-quaternary sandwicine derivatives which exhibit heart rhythm regulatory and adrenolytic properties. 10-bromosandwicine is prepared by brominating sandwicine and can subsequently be isomerized into 10-bromoisosandwicine.