| 摘要 |
Title compds. I(R1=H, C1-4 alkanoyl; R2 = C5-10 alkyl, alkenyl; R3=H, Me; Z=CH2COCHR4CH2, CH2CHR4COCH2, CH2CR5R6-CH2CH2, CH2CH2CR5R6CH2, CH2CR5:CHCH2, CH2CH:CR5CH2, HC:CR5CH2CH2, CH2CH2CR5:CH; R4=H, C1-4 alkoxycarbonyl; R5=H, C1-4 alkyl; R6=H, OH) were prepd. Thus, a mixt. of (±)-6a, 10a,-trans-1-hydroxy-3-(1,1-dimethyl heptyl)-6,6-dimethyl-6a,6,8,9,10,10a-hexahydro dibenzo≮b,d≉pyran-9-one dissolved in dichloromethane, triethyloxonium tetrafluoroborate and ethyldiazoacetate was stirred for 1 hr at 5≰C to give (±)6a, 11a-trans-1-hydroxy-3-(1,3-dimethylheptyl)-6,6-dimethyl-9-oxo-10-ethoxycarbonyl-6,6a,7,8,9,10,11,11a-octa hydrobenzo≮b≉cyclohepta≮d≉pyran. I had antihypertensive activity.
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