| 摘要 |
Title compds. (I; R1= C1-5 alkanol; R2= H, C1-3 alkyl; m = 1-3) were prepd. by the reduction of III. Thus, reaction of 264 g 1-(2-acetoxyethyl)-2-pyrrolidinone with 194 g dimethyl sulfate at 60-63≦̸C for 1.5 hr, followed by addn. of MeONa in EtOh at 15≦̸C, and addn. of MeNO2 after 1 hr, gives after 5 hr at reflux 1-(2-hydroxyethyl)-2-(nitromethylene)pyrrolidine(III). Hydrogenation of III in MeOH over Raney-Ni at 0-60≦̸C, 50 atm gives after 15 min 73% I.
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