Azabicycloalkane derivatives, process for their preparation, and a pharmaceutical composition containing them.

摘要

Compounds of formula (I) or pharmaceutically acceptable salts thereof or solvates of the compounds or salts: <CHEM> wherein: R1 is hydroxy, C1-4 alkoxy or an in-vivo hydrolysable acyloxy group: R2 is hydrogen, C1-4 alkyl, hydroxy, C1-4 alkoxy or an in-vivo hydrolysable acyloxy group; or R1 and R2 together are C1-2 alkylenedioxy; A is a group <CHEM> where E is <CHEM> where p is 0 to 2; Z is O or S n is 0 or 1; and one of R6 and R7 when n=0 is C1-4 alkyl and the other is hydrogen or C1-4 alkyl or one of R6, R7 and R8 when n= 1 is C1-4 alkyl and the other two are the same or different and are hydrogen or C1-4 alkyl; and R5 is C1-7 alkyl; a group -(CH2)sR13 where s is 0 to 2 and R13 is a C3-8 cycloalkyl group; a group -(CH2)tR14 where t is 1 or 2 and R14 is C2-5 alkenyl or a phenyl group optionally @