| 摘要 |
1533205 Complexes containing plasmin or plasminogen MICHAEL REESE RESEARCH FOUNDATION 19 Sept 1977 [24 Sept 1976] 38933/77 Heading A5B [Also in Division C3] Pharmaceutical compositions, which may be utilised in the intravenous treatment of a blood clot in the circulatory system, comprises a physiological saline solution of a substantially equimolar complex of a substance which forms with human plasminogen a complex useful for its fibrinolytic activity (preferably staphylokinase or streptokinase) with a plasmin light (B) chain (defined) having a site which shows serine protease activity. The complex is preferably of the reaction product of streptokinase with the plasmin light (B) chain having a site showing serine protease activity, or the reduction product of an equimolar complex of streptokinase with plasminogen or plasmin, which may have a bovine plasminogen activator activity, as measured on a casein substrate, of from 100 to 600 CTA units/nmole of protein. |
