摘要 |
Title compds. (I; R3 = H, C1-4 alkyl, C5-6 cycloalkyl, Ph, benzyl, C3-5 alkanoyloxymethyl; X = halogen, CF3, CCl3, C1-6 satd. alkyl, benzyl; A = direct bond, C1-3 alkylene), useful as diuretics, were prepd. by hydrolysis of IV(D = -CH2 OH, -CH2-halogen, etc.). Thus, 7,8 g 4-phenylmercapto-3-(1-pyrrolidinyl)-5-sulfamoylbenzoic acid was dissolved in acetic acid and 30 %-H2O2, and stirred for 20 hr to give 4-phenylsulfoxy-3-(1-pyrrolidinyl)-5-sulfamoylbenzoic acid.
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