STEROIDS OF THE PREGNANE SERIES SUBSTITUTED IN THE 17-POSITION AND THE PREPARATION AND USE THEREOF

摘要

This invention provides a steroid of the general formula wherein X represents hydrogen, fluorine, chlorine or methyl, Y represents hydrogen, hydroxy, formyloxy or alkanoyloxy having up to 6 carbon atoms, Z represents hydrogen or methyl, V represents methylene, ethylidene, hydroxymethylene or vinylidene, and R1 represents (C1-C6)alkyl optionally interrupted by an oxygen atom, and R2 represents hydrogen or (C1-C6)alkyl, or R1 and R2 together represent tetramethylene if Y represents hydroxy, formyloxy or alkanoyloxy. These compounds have good pharmacological activity and also are useful intermediates for the preparation of 11.beta.-hydroxy steroids which themselves are useful medicaments.