发明名称 |
NYA BICYKLISKA FOERENINGAR OCH FOERFARANDE FOER DERAS FRAMSTAELLNING |
摘要 |
<p>New bicyclic compounds of the general formula (I), <IMAGE> wherein Y<1> and Y<2> represent a removable carbonyl protecting group, and Q is a C1-5 alkyl group or a substituted benzyl group, are prepared, e.g. in the way that leaving group X of a compound having the general formula (V), <IMAGE> wherein X is a selectively removable esterifying group, is removed, the carboxy group of the resulting new compound of the general formula (IV> <IMAGE> is activated and reacted then with a salt of a malonic acid hemiester, wherein the alcohol component is a C1-5 aliphatic alcohol or a substituted benzyl alcohol, the resulting new compound of the general formula (III> <IMAGE> is reacted with a sulfonic azide in the presence of a tertiary amine, and the resulting new compound of the general formula (II> <IMAGE> is subjected to ring closure. The compounds of the general formula (I) are pharmacologically active as beta -lactamase inhibitors or can be converted into pharmacologically active thienamycin derivatives.</p> |
申请公布号 |
FI824520(A0) |
申请公布日期 |
1982.12.30 |
申请号 |
FI19820004520 |
申请日期 |
1982.12.30 |
申请人 |
RICHTER GEDEON VEGYESZETI GYAR R.T |
发明人 |
LEMPERT, KAROLY;DOLESCHALL, GABOR;FETTER, JOZSEF;HORNYAK, GYULA;NYITRAI, JOZSEF;SIMIG, GYULA;ZAUER, KAROLY;HARSANYI, KALMAN;FEKETE, GYOERGY;SZPORNY, LASZLO;HAJOS, GYOERGY |
分类号 |
A61K31/397;A61K31/40;A61P31/04;B01J31/00;C07B61/00;C07D205/08;C07D207/26;C07D207/277;C07D405/04;C07D411/04;C07D477/00;C07D477/18;(IPC1-7):C07D/ |
主分类号 |
A61K31/397 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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