| 摘要 |
NEW MATERIAL:A compound of formula I [A and B are each carbonyl or one of them is methylene, the other being carbonyl; Z is O, S, (substituted) N or methylene; n is 2-6; R is of formula II or III (R<1> is H or OH; R<2> is (substituted) phenyl or 2-pyridyl)] and its salt. EXAMPLE:4-(4-(4-phenyl)-1-piperidinyl)butyl-2,3,4,5-tetrahydro-1,4-ben zoxazepin-5- one. USE:A therapeutic drug for psychoneurosis. High in the affinity for (sigma-receptor, while low in the affinity for D2 receptor. PREPARATION:For example, a compound of formula IV is reacted with a dibromoalkane into a compound of formula V, which is then condensed with an amine derivative of formula RH through a conventional process, thus obtaining the objective compound of the formula I (where, A is carbonyl, B is methylene, and Z is O). |
