SUSPENSION OF MICROENCAPSULATED BACAMPICILLIN ACID ADDITION SALT FOR ORAL, ESPECIALLY PEDIATRIC, ADMINISTRATION

摘要

A novel formulation of bacampicillin for oral administration is disclosed. Microcapsules comprising an acid addition salt of bacampicillin coated with a mixture of ethyl cellulose:water-soluble or waterpermeable filler material are suspended in a buffered vehicle having a pH of at least 6.9. The novel suspension is characterized by palatable taste, surprisingly good stability and enhanced bioavailability after oral administration. The novel suspension is well suited for multiple dose oral administration. The preferred filled material is hydroxypropyl cellulose.