OLIGONUCLEOTIDES CONTAINING AN ANTISENSE SEQUENCE STABILISED BY A SECONDARY STRUCTURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

摘要

The invention concerns oligonucleotides containing at least a secondary structure capable of modifying or inhibiting the expression of a target gene in vivo or in vitro. The invention is characterised in that it comprises an antisense sequence and optionally a supplementary nucleotide sequence at one and/or the other ends of the antisense sequence, selected such that the secondary structure(s) are broken down when the oligonucleotide is fixed on the target nucleic acid. The invention also concerns pharmaceutical compositions containing said oilgonucleotides.