摘要 |
The furan derivative of formula (I) …<CHEM>… is prepared by reacting cystamine of formula (II) …<CHEM>… either with a nitroethenamine of formula (III) …<CHEM>… where L is a leaving group such as alkylthio, e.g. methylthio, or with a compound of formula (IV) …<CHEM>… where L is a leaving group as defined above, followed by reaction with methylamine, to give a disulphide of formula (V) …<CHEM>… which is then reacted with 5-[(dimethylamino)methyl]-2-furanmethanol under acid conditions. |