METHODS OF PURIFYING IMMUNOLOGLOBULINS

摘要

The disclosure provides methods for purifying certain subclasses of immunoglobulins from biological fluids, such as, e.g., serum. The purification process involves the precipitation of non-immunoglobulin proteins with caprylic acid, followed by the precipitation of euglobulin immunoglobulins (e.g., IgM) by desalting. The methods are of use in a large-scale commercial production of various antibodies, e.g., anti-thymocyte antibodies as exemplified in the disclosure. Compositions produced by the methods disclosed as well as uses for such compositions are provided.