发明名称 |
A process for resolving, optionally substituted, mandelic acids by salt formation with a chiral base cyclic amide |
摘要 |
The present invention relates to a new process for the resolution of mandelic acid derivatives from racemic mandelic acid derivative mixtures by salt formation with chiral base cyclic amides; to the resolved mandelic acid cyclic amide salts (see, for example, formula IIa), as well as certain other metal and amine salts of the mandelic acid derivatives, and to the use of the resolved mandelic acid derivatives as intermediates suitable for large-scale manufacturing of, for example, pharmaceutical compounds; Formula IIa, wherein R is selected from CHF2, H, C1-6 Alkyl, CH2F, CHCl2 and CClF2; and wherein n is 0, 1 or 2; R1 is H or C1-6 Alkyl and X is H, halo or C1-6 Alkyl. |
申请公布号 |
ZA200604192(B) |
申请公布日期 |
2007.11.28 |
申请号 |
ZA20060004192 |
申请日期 |
2006.05.24 |
申请人 |
ASTRAZENECA AB. |
发明人 |
BLIXT, HANS JORGEN;GATTI, ROBERTO GIUSEPPE PAOLO;ZARAMELLA, SIMONE;ZISTLER, ANDREA;BOSSON, BO LARS GUSTAF;SENIOR, MICHAEL WILLIAM;VOGTLI, KURT |
分类号 |
C07C;C07C51/487;C07C59/64;C07C231/20;C07C237/24 |
主分类号 |
C07C |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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