发明名称 |
1-(4-AMINOPHENYL)-4-METHYL-7, 8-METHYLENEDIOXY- 3, 4-DIHYDRO-5H-2, 3-BENZODIAZEPINE, OPTICAL ACTIVE COMPOUND AND RACEMATE THEREOF, ACID ADDUCT OF SAID COMPOUND, PRODUCTION THEREOF, DRUG CONTAINING AFOREMENTIONED COMPOUND, PRODUCTION OF SAID DRUG AND THERAPEUTIC METHOD THEREBY |
摘要 |
The invention relates to new 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzo diazepi ne of formula (1), optically active isomers and acid addition salts thereof as well as to pharmaceutical compositions containing these compounds. <IMAGE> (I) The new compounds of formula (I) can be prepared by reducing 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine of formula (II) with an inorganic or organic-inorganic and/or complex metal hydride and, if desired, separating the optically active forms of the compound of formula (I) thus-obtained and, if desired, converting the base or bases into acid addition salts or converting the salts into the free bases(s). <IMAGE> (II) The new compound of formula (I) possesses significant central nervous effects and can advantageously be used in the therapy. |
申请公布号 |
JPS6399073(A) |
申请公布日期 |
1988.04.30 |
申请号 |
JP19870201967 |
申请日期 |
1987.08.14 |
申请人 |
BIOGAL GYOGYSZERGYAR |
发明人 |
ENOEE KOEEROESHI;TEIBORU RAANGU;FUERENTSU ANDORAASHI;PAARU BERUZENII;PEETERU BOTOUKA;TAMAASHIYU HAAMORI;KATARIN GORUDOSHIYUMITSUTO NEEE HORUBUAATO;YOOJIEFU BORUSHII;ISHIYUTOBUAAN EREKESHIYU;ZUZA RAANGU NEEE RIIMERU |
分类号 |
C07D405/10;A61K31/55;A61K31/551;A61P25/26;C07D491/04;C07D491/056 |
主分类号 |
C07D405/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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