The present invention relates to an insulin analog that has a reduced insulin titer and a reduced insulin receptor binding affinity compared to the native form for the purpose of increasing the blood half-life of insulin, a conjugate prepared by linking the insulin analog and a carrier, a long-acting formulation including the conjugate, and a method for preparing the conjugate.
申请公布号
HK1211944(A1)
申请公布日期
2016.06.03
申请号
HK20150112526
申请日期
2015.12.18
申请人
HANMI PHARM. CO. LTD.
发明人
HWANG, SANG YOUN;HUH, YONG HO;KIM, JIN YOUNG;HONG, SUNG HEE;CHOI, IN YOUNG;JUNG, SUNG YOUB;KWON, SE CHANG;KIM, DAE JIN;KIM, HYUN UK;JANG, MYUNG HYUN;KIM, SEUNG SU