Process for the preparation of azabicyclo(3.2.0)-hept-2-ene derivatives.

摘要

A process for the preparation of an antibacterially active compound of the formula (I):
<Chemistry id="chema01" num="0001"><Image id="ia01" he="29" wi="84" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>and salts and esters thereof wherein R<Sup>1</Sup> and R<Sup>2</Sup> independently are hydrogen or an organic group, and R<Sup>3</Sup> is an organic group bonded via a carbon atom to the sulphur atom, which comprises reacting a compound of the formula (II):
<Chemistry id="chema02" num="0002"><Image id="ia02" he="30" wi="78" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R<Sup>4</Sup> is an organic group different to H<Sup>3</Sup> and R<Sup>a</Sup> is hydrogen or a carboxy-blocking group, with a thiol R<Sup>3</Sup>SH or reactive derivative thereof. In addition certain compounds within the formula (II) are novel and useful antibacterial agents in their own right.