D-Allose derivative and preparation method therefor

摘要

3-[3-(2-Haloethyl)-3-nitrosoureido]-3-deoxy-D-alloses are new, antitumor compounds having a far lower myelotoxicity as compared with conventional antitumor agents. They are obtained by treating 3-[3-(2-haloethyl)ureido]-3-deoxy-1,2,5,6,-di-O-isopropylidene- alpha -D-allofuranoses with a nitrosating agent and then hydrolyzing the protective group in the presence of an acid.