| 摘要 |
PURPOSE:To obtain a bacterium-derived hypotensor having low side effects, readily usable, containing an extract of a cell of lactic acid bacillus with water as an active ingredient. CONSTITUTION:A cell of lactic acid bacillus (e.g. Lactobacillus casei, L. plantarum, etc.) is suspended in water at >=50 deg.C in 10-80mg/ml and extracted under a preferable condition for 10-60min. After the extraction is over, the cell, an insoluble substance comprising fragments thereof, etc., are removed to give an extracted solution, which is concentrated as it is and dried to give a hypotensor. Salts and other low-molecular weight substances are removed to give the more effective hypotensor (main components are 37% saccharide, 15% protein and 32% nucleic acid; yield is 10mg based on 100mg dried cell). The hypotensor can be readily made into any dosage form and can be administered orally (including sublingual administration) or parenterally (intravenous injection, intravenous drip, etc.). |
