发明名称 MEJORAS EN UN PROCEDIMIENTO PARA LA PREPARACION DE PENICI- LINAS Y DERIVADOS DE PENICILINAS.
摘要 <p>A process for the preparation of a compound of formula (I): <IMAGE> (I) wherein R1 is hydrogen, hydroxy, mercapto radical, a substituted or unsubstituted methoxy, ethoxy, methyl, ethyl, methyl thio, or ethylthio radical, a carbamoyloxy, carbamoylthio, C1-6 alkanoyloxy, C1-6 alkanoylthio, cyano, carboxy or carbamoyl radical; and R2 represents an acyl group which comprises hydrolysis of a compound of formula (II): <IMAGE> (II) wherein R1 and R2 are as defined with respect to formula (I) hereinbefore and R3 represents benzyl or substituted benzyl; wherein the hydrolysis is catalyzed by a microbial serine proteinase.</p>
申请公布号 ES506854(D0) 申请公布日期 1982.08.16
申请号 ES19540005068 申请日期 1981.11.04
申请人 BEECHAM GROUP LIMITED 发明人
分类号 C07D499/08;C12N11/08;C12N11/10;C12P37/00;(IPC1-7):12P37/00 主分类号 C07D499/08
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