Dichloroamino acid derivatives useful as potent germicidal and fungicidal agents.

摘要

Dichloroamino acid derivatives having the formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="26" wi="41" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein
<UnorderedLists id="ula01" listStyle="none"><ListItem>H<Sup>1</Sup> and R<Sup>2</Sup> are independently
<UnorderedLists id="ula02" listStyle="none"><ListItem>(a) lower alkyl;</ListItem><ListItem>(b) lower cycloalkyl;</ListItem><ListItem>(c) lower (cycloalkyl-alkyl);</ListItem><ListItem>(d) phenyl or lower alkyl-substituted phenyl;</ListItem><ListItem>(e) halosubstituted phenyl;</ListItem><ListItem>(f) lower alkoxy-substituted phenyl;</ListItem><ListItem>(g) phenyl (lower alkyl); or</ListItem></UnorderedLists></ListItem><ListItem>R<Sup>1</Sup> and R<Sup>2</Sup> joined together form lower alkylene; and Z is
<UnorderedLists id="ula03" listStyle="none"><ListItem>(a) lower alkylene;</ListItem><ListItem>(b) -(CH<Sub>2</Sub>)<Sub>n</Sub>-phenylene-(CH<Sub>2</Sub>)<Sub>m</Sub>- wherein n and m independently are integers from 0 to 5; (c)
<Chemistry id="chema02" num="0002"><Image id="ia02" he="11" wi="48" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry></ListItem><ListItem>(d)
<Chemistry id="chema03" num="0003"><Image id="ia03" he="10" wi="49" file="IMGA0003.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry></ListItem><ListItem>(e) -(CH<Sub>2</Sub>)<Sub>n+1</Sub>-O-(CH<Sub>2</Sub>)<Sub>m</Sub>-; wherein n is an integer from 0 to 3 and m an 0-20; (f)
<Chemistry id="chema04" num="0004"><Image id="ia04" he="10" wi="28" file="IMGA0004.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>or</ListItem><ListItem>(g)-
<Chemistry id="chema05" num="0005"><Image id="ia05" he="11" wi="32" file="IMGA0005.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>or a pharmaceutically acceptable salt thereof are prepared from chlorination of corresponding amino acids, and are found to be potent germicidal and fungicidal agents.</ListItem></UnorderedLists></ListItem></UnorderedLists>