| 摘要 |
PURPOSE:To prepare an ester useful as an intermediate of pharmaceuticals and pesticides, in high yield, without side reaction, by carboalkoxylating an organic halide having easily eliminable H at the beta-position in the presence of a carbonylation catalyst containing an organic arsenic compound or an organic antimony compound. CONSTITUTION:The organic halide of formulaI(R<1>-R<4> are H or organic group; X is halogen) (e.g. alpha-phenylethyl bromide) is carboalkoxylated to the ester of formula II by the reaction with the alcohol of formula R<5>OH (R<5> is organic group) and CO. The above reaction is carried out using a carbonylation catalyst containing an organic arsenic compound or an organic antimony compound (e.g. tetrakistriphenylarsine palladium), pref. in the presence of a basic compound such as an amine, caustic soda, etc. The side reactions such as production of olefins or ethers can be suppressed, and the reaction can be easily operated. |
