| 摘要 |
NEW MATERIAL: The 2-butenoic acid compound of formulaI(X is halogen). EXAMPLE:4-(2-Chloro-fluorophenyl)-4-oxo-2-butenoic acid. USE:It has antiphlogistic, analgesic and antipyretic activities, and is useful as a drug. PROCESS:The compound of formulaIis prepared by reacting e.g. maleic anhydride of formulaIIwith a halogenated benzene of formula III in the presence of a Lewis acid catalyst such as boron chloride pref. at room temp.-100 deg.C. |
