ANTIBIOTIC NEPLANOCINS

摘要

The present invention provides antibiotic neplanocins of the following formula wherein X is an NH2, -OH, -SH, or -SCH3 group or a C1 atom, R is a hydrogen atom or a protective group for the -OH group, and Z is the group; in which Y is -O- or a valence bond, and R is a hydrogen atom or a protective group for the -OH group, or the group; in which Y is -O- or a valence bond. They are prepared by a process which comprises culturing a neplanocins producing microorganism belonging to the genus Ampullariella in a nutrient medium consisting of assimilable carbon and nitrogen sources and inorganic substances, and isolating neplanocin-A, -C, -D, -B and -F from the cultured mass.