| 摘要 |
Title compds. (I; Y1 = III, IV, V; R1 = benzyl, benzoyl, C1-5 alkanoyl; R4 = H, C1-6 alkyl; R5 = H, methyl, ethyl; R6 = H, carbobenzyloxy, formyl, C2-5 alkanoyl, C1-6 alkyl; Z = C1-9 alkylene; W = H, methyl, pyridyl, piperidyl), useful as analgesics, were prepd. by the acylation of II(R = H; Y = III IV(R = R↿), V). Thus, 2.2 ml pyridine was added in a suspension of 222 mg 5,6,6a,7,10,10a-hexahydro-1-hydroxy-6β-methyl-3-(2-heptyloxy)benzo[c quinolin-9(8H)-one and 2.2 ml anhyd. acetic acid, and reacted at room temp for 1.5 hr to give 5,6,6a,7,10,10a-hexahydro-1-acetoxy-6β-methyl-3-(2-heptyloxy)benzo[c quinolin-9(8H)-one isomer.
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