| 摘要 |
Aromatase inhibitors are provided having the formula <IMAGE> +TR <IMAGE> wherein represents a single or double bond; R is hydrogen or C1-4 alkyl; R1 is methyl or ethyl; R2 is (H) (OR8) or =O; R3 is H or C1-3 alkyl; R4 is H or OR8; R5 is H, C1-3 alkyl or, when the 5,6-bond is saturated, R5 is divalent =O; R6 and R7 are each H or C1-3 alkyl; and R8 is H or C2-4 alkanoyl. Intermediates useful in preparing the foregoing aromatase inhibitors, and methods of using the aromatase inhibitors of the invention are also provided. |
