| 摘要 |
<p>7-substituted camptothecin derivatives of the general formula
<CHEM>
wherein R represents -CHO, -CH2OR min , -CH(OR min )2 or -CH=N-X where R min is a lower alkyl group having from 1 to 6 carbon atoms or a phenylalkyl group having from 1 to 3 carbon atoms in the alkylene moiety thereof, and X is a hydroxyl group or -NR<1>R<2> where R<1> and R<2> are the same or different and each represent hydrogen atom or a lower alkyl group having from 1 to 6 carbon atoms, or when R<1> is hydrogen, R<2> may be a lower alkyl group having from 1 to 6 carbon atoms, a substituted or unsubstituted aryl group, a carbamoyl group, an acyl group, an aminoalkyl group or an amidino group, or when R<1> is a lower alkyl group, R<2> may be an aminoalkyl group, or R<1> and R<2> may be combined together with the nitrogen atom to which they are attached to form a heterocyclic group which may be interrupted by one or two nitrogen, oxygen and/or sulfur atoms, and the quaternary salts thereof. </p> |
