| 摘要 |
<p>2'-N-Acyl and alkyl fortimicin B and fortimicin n derivatives, 4,2'-N, N'-diacyl and dialkyl derivatives, 4 N-acyl-2'-N-alkyl and 4-N-alkyl-2'-N-acyl fortimicin B derivatives represented by the formula wherein: R is acyl, aminoaevl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, hydroxyacyl, an amino acid residue, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralky, N-loweralkylaminohydroxyloweralkyl or N,N-dilowera1kylnmino-hydroxyloweralkyl; and R1 is acyl, aminoaeyl, N-monolower-alkylaminoacyl, N,N-diloweralkylaminoaeyl, hydroxy-substituted aminoacyl, an amino acid residue, hydroxyacyl, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminolower-alkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N,N-diloweralkyl-aminohydroxyloweralkyl or hydroqen and the pharmaccutically acceptable salts thereof; pharmaceutical compositions containing the compounds; and methods of makinq and using the compounds. The fortimicin derivatives of this invention are antiblotics.</p> |
